Vasiliki Papandreou was born in Patras, Greece. She finished her high school studies in the United States, and went on to receive a Bachellor of Fine Arts in Painting from the Minneapolis College of Art & Design and a Master of Arts in History of Art & Museology from the University of Minnesota. She returned to Athens, Greece, in 1964.
Papandreou has had six personal exhibitions of her paintings in Minnesota and Athens, including Katia Vardoulaki & Vasiliki Papandreou: Old Buildings in Contemporary Landscapes, Center for Visual and Applied Arts, Pallini, Attiki (2006). She has also participated in many group exhibitions. Besides painting, Papandreou has worked as a Museum Assistant and Lecturer; taught Studio Art to children as well as History of Art at the University of Minnesota, University of Maryland and University of La Verne in Athens. She lectured in Art History at Deree College for thirty years, leaving her post in 2004.
Vasiliki Papandreou was instrumental in creating a Center of Visual & Applied Arts in Kantza, Pallini, inaugurated in September 2006, and the Association of Visual Artists of Mesogeia in Attica in 2005, of which she is a member.