Aliki Tzen was born on 3 June 1949 in Athens, Greece. She graduated from Pierce College (1967) and continued her studies at the School of Philosophy of the National Capodistrian University of Athens (1962-1972). She received certificates in painting from Saint Martin's School of Art, London (1972) and the École Nationale Supérieure des Beaux-Arts, Paris (1972-1975). She studied aesthetics at Paris I, Sorbonne (1980-1982) under Iannis Xenakis. The Greek State Scholarship Foundation - IKY enabled Tzen to pursue postgraduate studies at the Athens School of Fine Arts (1983-1986) under Nikos Kessanlis.
Alongside her career in the field of the visual arts, Aliki Tzen has been active in the following capacities: Responsible for the Painting Department of the Chamber of Fine Arts of Greece (1982-); Founding Member and President of the Greek Society for Dyslexia (1984-); Organizer of Annual Painting Exhibitions at the Ionidion Experimental High School (1990-1995); and Responsible for Cultural Activities at the Ionial School (2000).
Aliki Tzen has presented the following personal exhibitions: French Quarter, Paris (1996). She has also taken part in the following group exhibitions: Aliki Tzen & Louiza Kakissi, Municipal Theater of Piraeus (1966); Panhellenic Exhibition, Zappeion, Athens (1974); Art in the Municiapalities, Attiki (1985); and A Tribute to the Alumnae Artists of Pierce College, Cultural Centre of The American College of Greece, Plaka (2006).